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研究業績

2024年
Keisuke Yuzu, Ching-Yang Lin, Po-Wei Yi, Chih-Hao Huang, Hiroshi Masuhara*, and Eri Chatani*
"Spatiotemporal formation of a single liquid-like condensate and amyloid fibrils of α-synuclein by optical trapping at solution surface"
Proc. Natl. Acad. Sci. USA, 121, e2402162121 (2024)

Basudev Maity, Shiori Kameyama, Jiaxin Tian, Thuc Toan Pham, Satoshi Abe, Eri Chatani, Kazuyoshi Murata, and Takafumi Ueno*
"Fusion of amyloid β with ferritin yields an isolated oligomeric β-sheet-rich aggregate inside the ferritin cage"
Biomater. Sci. 12, 2408-2417 (2024)

Keisuke Yuzu, Hiroshi Imamura, Takuro Nozaki, Yuki Fujii, Shaymaa Mohamed Mohamed Badawy, Ken Morishima, Aya Okuda, Rintaro Inoue, Masaaki Sugiyama, and Eri Chatani*
"Mechanistic modeling of amyloid oligomer and protofibril formation in bovine insulin"
J. Mol. Biol. 436, 168461 (2024)

Shohei Maekawa*, Keisuke Yuzu, Eri Chatani, and Kenichi Morigaki
"Oligomerization and aggregation of NAP-22 with several metal ions"
Neurosci Lett. 821, 137623 (2024)

2023年
Minami Kurokawa, Tomoya Ohtsu, Eri Chatani, and Atsuo Tamura*
"Hyper thermostability and liquid-crystal-like properties of designed α-helical peptide nanofibers"
J. Phys. Chem. B. 127, 8331-8343 (2023)

Mika Ishigaki*, Yoshiki Kato, Eri Chatani, and Yukihiro Ozaki
"Variations in the Protein Hydration and Hydrogen-Bond Network of Water Molecules Induced by the Changes in the Secondary Structures of Proteins Studied through Near-Infrared Spectroscopy"
J. Phys. Chem. B 127, 7111-7122 (2023)

Mao Fukuyama*, Suguru Nishitani, Yoko Maruyama, Taiki Ozawa, Shunsuke Tomita, Yumiko Ohhashi, Motohiro Kasuya, Masao Gen, Eri Chatani, Kentaro Shiraki, and Akihide Hibara*
"Detection of fibril nucleation in micrometer-sized protein condensates and suppression of Sup35NM fibril nucleation by liquid-liquid phase separation"
Anal. Chem. 95, 9855-9862 (2023)

Po-Wei Yi, Wei-Hsiang Chiu, Shuichi Toyouchi*, Roger Bresoli-Obach*, Johan Hofkens, Eri Chatani, Yoichiroh Hosokawa*, Teruki Sugiyama*, and Hiroshi Masuhara*
"Two-stage optical trapping and assembling of protein at air/solution interface"
App. Phys. Express 16, 025501 (2023)

2022年
Naoki Yamamoto*, Rintaro Inoue, Yoshiteru Makino, Hiroshi Sekiguchi, Naoya Shibayama, Akira Naito, Masaaki Sugiyama, and Eri Chatani*
"Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen"
J. Phys. Chem. B 126, 10797-10812 (2022)

Yuki Yoshikawa, Keisuke Yuzu, Naoki Yamamoto, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Tetsushi Iwasaki, Masatomo So, Atsuo Tamura, and Eri Chatani*
"Pathway dependence of the formation and development of prefibrillar aggregates in insulin B chain"
Molecules 27, 3964-3964 (2022)

Naoki Yamamoto* and Eri Chatani
"Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen"
Biophysics and Physicobiology 19, e190017 (2022)

2021年
Po-Wei Yi, Wei-Hsiang Chiu, Tetsuhiro Kudo, Teruki Sugiyama*, Roger Bresoli-Obach*, Johan Hofkens, Eri Chatani, Ryohei Yasukuni, Yoichiroh Hosokawa*, Shuichi Toyouchi*, and Hiroshi Masuhara*
"Cooperative optical trapping of polystyrene microparticle and protein forming a submillimeter linear assembly of microparticle"
J. Phys. Chem. C 125, 18988-18999 (2021)

Masahiro Noji, Tatsushi Samejima, Keiichi Yamaguchi, Masatomo So, Keisuke Yuzu, Eri Chatani, Yoko Akazawa-Ogawa, Yoshihisa Hagihara, Yasushi Kawata, Kensuke Ikenaka, Hideki Mochizuki, Jozsef Kardos, Daniel E Otzen, Vittorio Bellotti, Johannes Buchner, and Yuji Goto*
"Breakdown of supersaturation barrier links protein folding to amyloid formation"
Commun. Biol. 4, 120 (2021)

Keisuke Yuzu, Naoki Yamamoto, Masahiro Noji, Masatomo So, Yuji Goto, Tetsushi Iwasaki, Motonari Tsubaki, and Eri Chatani*
"Multistep changes in amyloid structure induced by cross-seeding on a rugged energy landscape"
Biophys. J. 120, 284-295 (2021)

Hamed A Abosharaf, Yuki Sakamoto, Aliaa M Radwan, Keisuke Yuzu, Mika Fujimura, Thoria Diab, Tarek M Mohamed, Eri Chatani, Tetsunari Kimura, and Motonari Tsubaki*
"Functional assembly of caenorhabditis elegans cytochrome b-2 (Cecytb-2) into phospholipid bilayer nanodisc with enhanced iron reductase activity"
Biomolecules 11, 96 (2021)

Eri Chatani*, Keisuke Yuzu, Yumiko Ohhashi, and Yuji Goto
"Current understanding of the structure, stability and dynamic properties of amyloid fibrils"
Int. J. Mol. Sci. 22, 4349 (2021)

柚 佳祐, 茶谷 絵理*
「アミロイド線維の伝播に見られる構造の保存と変化」
C & I Commun. 46, 19-21 (2021)

山本 直樹, 茶谷 絵理*
「アミロイド線維前駆中間体の観測とそれを標的とした線維形成阻害―インスリン由来モデルペプチドとフィブリノーゲンを用いた検証―」
生物物理 61, 236-239 (2021)

茶谷 絵理*
「核形成を経てアミロイド線維の生成に至るメカニズム」
膜 46, 19-24 (2021)

2020年
Takato Hiramatsu, Naoki Yamamoto, Seongmin Ha, Yuki Masuda, Mitsuru Yasuda, Mika Ishigaki, Keisuke Yuzu, Yukihiro Ozaki, and Eri Chatani*
"Iodine staining as a useful probe for distinguishing insulin amyloid polymorphs"
Sci. Rep. 10, 16741-16741 (2020)

Masaki Okuda, Takato Hiramatsu, Mitsuru Yasuda, Mika Ishigaki, Yukihiro Ozaki, Michitoshi Hayashi*, Keisuke Tominaga, and Eri Chatani*
"Theoretical modeling for electronic structure of polyiodide species included in α-cyclodextrin"
J. Phys. Chem. B 124, 4089-4096 (2020)

Mika Ishigaki*, Kana Morimoto, Eri Chatani*, and Yukihiro Ozaki
"Exploration of insulin amyloid polymorphism using Raman spectroscopy and imaging"
Biophys. J. 118, 2997-3007 (2020)

櫻井 一正, 茶谷 絵理, 後藤 祐児*
「タンパク質に対する圧力研究の新展開-基本熱力学から,分子構造に基づく理解,アミロイド線維まで」
化学 75, 39-44 (2020)

2019年
Naoki Yamamoto, Taiki Akai, Rintaro Inoue, Masaaki Sugiyama, Atsuo Tamura, and Eri Chatani*
"Structural insights into the inhibition of amyloid fibril formation by fibrinogen via interaction with prefibrillar intermediates"
Biochemistry 58, 2769-2781 (2019)

El Behery Mohammed, Koichi Asada, Fusako Takeuchi, Tetsunari Kimura, Eri Chatani, and Motonari Tsubaki*
"Elucidation of molecular functions of human tumor suppressor protein 101F6 by reconstitution into phospholipid bilayer nanodiscs"
KIMIKA Journal of the Kapisanang Kimika ng Pilipinas 30, 1-3 (2019)

Ryosuke Matsubara*, Tomoaki Kaiba, Akito Nakata, Tatsushi Yabuta, Masahiko Hayashi, Motonari Tsubaki, Takashi Uchino, and Eri Chatani
"9-Aryl-3-aminocarbazole as an environment- and stimuli-sensitive fluorogen and applications in lipid droplet imaging"
J. Org. Chem. 84, 5535-5547 (2019)

茶谷 絵理, 後藤 祐児*
「分子夾雑のタンパク質物理化学−蛋白質凝集研究の進展とこれから」
現代化学 578, 26-30 (2019)

2018年
Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, and Eri Chatani*
"A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation"
Sci Rep. 8, 62 (2018)

Naoki Yamamoto, Shota Ito, Masahiro Nakanishi, Eri Chatani, Keiichi Inoue, Hideki Kandori, and Keisuke Tominaga*
"Effect of temperature and hydration level on purple membrane dynamics studied using broadband dielectric spectroscopy from Sub-GHz to THz regions"
J. Phys. Chem. B 122, 1367-1377 (2018)

Eri Chatani* and Naoki Yamamoto
"Recent progress on understanding the mechanisms of amyloid nucleation"
Biophys. Rev. 10, 527-534 (2018)

2017年
Ayame Nitani, Hiroya Muta, Masayuki Adachi, Masatomo So, Kenji Sasahara, Kazumasa Sakurai, Eri Chatani, Kazumitsu Naoe, Hirotsugu Ogi, Damien Hall, and Yuji Goto*
"Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation"
J. Biol. Chem. 292, 21219-21230 (2017)

Tsung-Han Liu, Ken-ichi Yuyama, Takato Hiramatsu, Naoki Yamamoto, Eri Chatani*, Hiroshi Miyasaka, Teruki Sugiyama*, and Hiroshi Masuhara*
"Femtosecond-laser-enhanced amyloid fibril formation of insulin"
Langmuir 33, 8311-8318 (2017)

2015年
Eri Chatani, Rintaro Inoue, Hiroshi Imamura, Masaaki Sugiyama, Minoru Kato, Masahide Yamamoto, Koji Nishida, and Toshiji Kanaya
"Early aggregation preceding the nucleation of insulin amyloid fibrils as monitored by small angle X-ray scattering"
Sci. Rep. 5, 15485 (2015)

茶谷 絵理
「プログラムされていないフォールディング−アミロイド線維の形成−」
生化学 87, 292-297 (2015)

井上 倫太郎、茶谷 絵理、金谷 利治
「小角X線散乱によるアミロイド線維形成機構に関する研究」
SPring-8/SACLA利用研究成果集 3, 2011B1996/BL40B2 (2015)

2014年
Eri Chatani, Yutaro Tsuchisaka, Yuki Masuda, Roumiana Tsenkova
"Water molecular system dynamics associated with amyloidogenic nucleation as revealed by real time near infrared spectroscopy and aquaphotomics"
PLoS One., 9, e101997 (2014)

Eri Chatani, Hiroshi Imamura, Naoki Yamamoto, and Minoru Kato
"Stepwise organization of the β-structure identifies key regions essential for the propagation and cytotoxicity of insulin amyloid fibrils"
J. Biol. Chem., 289, 10399-10410 (2014)

2013年
茶谷 絵理,井上 倫太郎,竹中 幹人,西田 幸次,金谷 利治
「超小角X線散乱によるインスリンアミロイド線維の構造解析」
SPring-8/SACLA利用研究成果集1, 2011B1951 (2013)

2012年
Eri Chatani, Hisashi Yagi, Hironobu Naiki, and Yuji Goto
"Polymorphism of β2-microglobulin amyloid fibrils manifested by ultrasonication-enhanced fibril formation in trifluoroethanol"
J. Biol. Chem. 287, 22827-22837 (2012)

茶谷 絵理、小沼 剛、後藤 祐児
「アミロイド線維伸長における中間体構造の捕捉と構造解析」
生物物理 52, 148-149 (2012)

2011年
Tsuyoshi Konuma†, Eri Chatani†, Masanori Yagi, Kazumasa Sakurai, Takahisa Ikegami, Hironobu Naiki, and Yuji Goto (†equally contributed)
"Kinetic intermediates of β2-microglobulin fibril elongation probed by pulse-labeling H/D exchange combined with NMR analysis"
J. Mol. Biol. 405, 851-862 (2011)

2010年
Yuichi Yoshimura, Kazumasa Sakurai, Young-Ho Lee, Takahisa Ikegami, Eri Chatani, Hironobu Naiki, and Yuji Goto
"Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy"
Protein Sci. 19, 2347-2355 (2010)

Eri Chatani†, Reina Ohnishi†, Tsuyoshi Konuma, Kazumasa Sakurai, Hironobu Naiki, and Yuji Goto (†equally contributed)
"Pre-steady-state kinetic analysis of amyloid fibrils of β2-microglobulin with tryptophan mutagenesis"
J. Mol. Biol., 400, 1057-1066 (2010)

Tsubasa Yamamoto, Eri Chatani, and Minoru Kato
"FTIR observation of compression recovery of the secondary structure of heat denaturated ribonuclease A in sucrose solution"
J. Phys. Conf. Ser., 215, 012155 (2010)

2009年
Eri Chatani, Young-Ho Lee, Hisashi Yagi, Yuichi Yoshimura, Hironobu Naiki, and Yuji Goto
"Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils"
Proc. Natl. Acad. Sci. USA, 106, 11119-11124 (2009)

Young-Ho Lee, Eri Chatani, Kenji Sasahara, Hironobu Naiki, and Yuji Goto
"A comprehensive model for packing and hydration for amyloid fibrils of β2-microglobulin"
J. Biol. Chem., 284, 2169-2175 (2009)

2008年
Yuji Goto, Hisashi Yagi, Keiichi Yamaguchi, Eri Chatani, and Tadato Ban
"Structure, formation and propagation of amyloid fibrils"
Curr. Pharm. Des., 14, 3205-3218 (2008)

Michiko Sakata†, Eri Chatani†, Atsushi Kameda, Kazumasa Sakurai, Hisonobu Naiki, and Yuji Goto (†equally contributed)
"Kinetic coupling of folding and prolyl isomerisation of β2-microglobulin studied by mutational analysis"
J. Mol. Biol., 382, 1242-1255 (2008)

2007年
Hyun-Jin Kim, Eri Chatani, Yuji Goto, and Seung R. Paik
"Seed-dependent accelerated fibrillation of α-synuclein induced by periodic ultrasonication treatment"
J. Microbiol. Biotechnol., 17, 2027-2032 (2007)

茶谷 絵理, 後藤 祐児
「圧力をもちいたアミロイド線維研究の展開」
高圧力の科学と技術, 17, 42-49 (2007)

2006年
Miho Kihara, Eri Chatani, Kentaro Iwata, Kaori Yamamoto, Takanori Matsuura, Atsushi Nakagawa, Hironobu Naiki, and Yuji Goto
"Conformation of amyloid fibrils of 2-microglobulin probed by tryptophan mutagenesis"
J. Biol. Chem., 281, 31061-31069 (2006)

Eri Chatani, Hironobu Naiki, and Yuji Goto
"Seeding-dependent propagation and maturation of β2-microglobulin amyloid fibrils under high pressure"
J. Mol. Biol., 359, 1086-1096 (2006)

茶谷 絵理, 内木 宏延, 後藤 祐児
「圧力でさぐるアミロイド線維の構造構築原理」
高圧力下の生物科学, pp. 85-92, さんえい出版 (2006)

2005年
Eri Chatani, Michiko Kato, Tomoji Kawai, Hironobu Naiki, and Yuji Goto
"Main-chain dominated amyloid structures demonstrated by the effect of high pressure"
J. Mol. Biol., 352, 941-951 (2005)

Miho Kihara, Eri Chatani, Miyo Sakai, Kazuhiro Hasegawa, Hironobu Naiki, and Yuji Goto
"Seeding-dependent maturation of β2-microglobulin amyloid fibrils at neutral pH"
J. Biol. Chem., 280, 12012-12018 (2005)

Bakthisaran Raman, Eri Chatani, Miho Kihara, Tadato Ban, Miyo Sakai, Kazuhiro Hasegawa, Hironobu Naiki, Ch Mohan Rao, and Yuji Goto
"Critical balance of electrostatic and hydrophobic interactions is required for β2-microglobulin amyloid fibril growth and stability"
Biochemistry, 44, 1288-1299 (2005)

Eri Chatani and Yuji Goto
"Structural stability of amyloid fibrils of β2-microglobulin in comparison with its native fold"
Biochim. Biophys. Acta, 1753, 64-75 (2005)

茶谷 絵理, 後藤 祐児
「アミロイド線維形成機構?裏の世界の構築原理」
実験医学, 23, 2384-2390, 羊土社 (2005)

2004年
Takehiro Narimoto, Kazumasa Sakurai, Azusa Okamoto, Eri Chatani, Masaru Hoshino, Kazuhiro Hasegawa, Hironobu Naiki, and Yuji Goto
"Conformational stability of amyloid fibrils of β2-microglobulin probed by guanidine-hydrochloride-induced unfolding"
FEBS Lett., 576, 313-319 (2004)

Haruko Maeda, Eri Chatani, Tomohiro Koyama, Masataka Sugiura, Hirohisa Izumi, and Rikimaru Hayashi
"Indiscriminate glycosylation of procarboxypeptidase Y expressed in Pichia pastoris"
Carbohydr. Res., 339, 1041-1045 (2004)

茶谷 絵理
「圧力で探求するタンパク質疎水性コア構造: ウシ膵臓リボヌクレアーゼAを例として」
日本農芸化学会誌, 78, 407-409 (2004)

2003年
Tetsuya Kadonosono, Eri Chatani, Rikimaru Hayashi, Hideaki Moriyama, and Tatzuo Ueki
"Minimization of cavity size ensures protein stability and folding: structures of Phe46-replaced bovine pancreatic RNase A"
Biochemistry, 42, 10651-10658 (2003)

2002年
Eri Chatani, Rikimaru Hayashi, Claude Balny, and Reinhard Lange
"Comparison of heat- and pressure-induced unfolding of ribonuclease A: the critical role of Phe46 which appears to belong to a new hydrophobic chain-folding initiation site"
Biochemistry, 41, 4567-4574 (2002)

Eri Chatani, Rikimaru Hayashi, Hideaki Moriyama, and Tatzuo Ueki
"Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 A resolution"
Protein Sci., 11, 72-81 (2002)

Eri Chatani, Tetsuya Kadonosono, and Rikimaru Hayashi
"The structural basis for functionality and stability of hydrophobic core in RNase A as probed by the application of high pressure"
Advances in High Pressure Bioscience and Biotechnology II, pp. 87-94, Elsevier (2002)

2001年
Eri Chatani, Rikimaru Hayashi, Reinhard Lange, and Clande Balny
"Thermal and pressure stability of Phe46 mutants of ribonuclease A"
Trends in High Pressure Bioscience and Biotechnology, pp. 27-32, Elsevier (2001)

Eri Chatani and Rikimaru Hayashi
"Roles of each amino acid residues composing bovine pancreatic ribonuclease A"
J. Biosci. Bioeng., 92, 98-107 (2001)

2000年
Eri Chatani, Naoki Tanimizu, Hiroshi Ueno, and Rikimaru Hayashi
"Structural and functional changes in bovine pancreatic ribonuclease A by the replacement of Phe120 with other hydrophobic residues"
J. Biochem., 129, 917-922 (2000)

Eri Chatani, Naoki Tanimizu, Hiroshi Ueno, and Rikimaru Hayashi
"Expression of soluble bovine pancreatic ribonuclease A in Pichia pastoris and its purification and characterization"
Biosci. Biotechnol. Biochem., 64, 2437-2444 (2000)