最近の主な論文・特許です。
             
2014年 2013年 2012年 2011年 2010年 2009年 2008年
2007年 2006年 2005年 2004年 2003年 2002年 2001年 〜2000年
   2014年
論文
Tomoyo Andachi, Naoki Yamamoto, Atsuo Tamura, & Keisuke Tominaga (2014) Low-frequency Spectra of a Phospholipid Bilayer Studied by Terahertz Time-domain Spectroscopy. J. Infrared, Millimeter, and Terahertz Waves, 35, 147-157
Naoki Yamamoto & Atsuo Tamura (2014) Designing Cell-Aggregating Peptides without Cytotoxicity. Biomacromolecules, DOI:10.1021/bm4014414, in press
Fumi Shima, Yoko Yoshikawa, Min Ye, Mitsugu Araki, Shigeyuki Matsumoto, Jingling Liao, Lizhi Hu, Takeshi Sugimoto, Yuichi Ijiri, Azusa Takeda, Yuko Nishiyama, Chie Sato, Shin Muraoka, Atsuo Tamura, Tsutomu Osoda, Ken-ichiro Tsuda, Tomoya Miyakawa, Hiroaki Fukunishi, Jiro Shimada, Takashi Kumasaka, Masaki Yamamoto & Tohru Kataoka, (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc. Natl. Acad. Sci. USA, 110, 8182-8187.
   2013年
論文
Tomoki Sugihara, Itsuho Hayashi, Hiroshi Ohnishi, Kenjiro Kimura, & Atsuo Tamura. Sub-nanometer-resolution imaging of peptide nanotubes in water using frequency modulation atomic force microscopy (2013) Chemical Physics, 419, 74-77.
国内特許
特願2013-182954
レアメタル結合能を有する人工ペプチドおよびその利用, (2013), 田村厚夫、飯田禎弘 出願人
特願2013-222702
アミロイド分解能を有する人工ペプチドおよびその利用, (2013), 田村厚夫、飯田禎弘
   2012年
論文
Naoki Yamamoto, Ohki Kambara, Kohji Yamamoto, Atsuo Tamura, and Keisuke Tominaga (2012) Temperature and hydration dependence of low-frequency spectra of poly-L-glutamic acid with different secondary structure studied by terahertz time-domain spectroscopy. Soft Matter, 8, 1997-2006.
Shin Muraoka, Fumi Shima, Mitsugu Araki, Tomoko Inoue, Akiko Yoshimoto, Yuichi Ijiri, Nobuaki Seki, Atsuo Tamura, Takashi Kumasaka, Masaki Yamamoto and Tohru Kataoka (2012) Crystal Structure of the State 1 Conformations of GTP-bound H-Ras Protein and its oncogenic G12V and Q61L mutants. FEBS Lett., 586, 1715-1718.
国内特許
特許第4915986号 取得
金属イオン結合能およびナノチューブ形成能を有する環状ペプチドと、それを用いたペプチドで構成されるナノチューブ、並びにそれらの製造方法, (2012), 田村厚夫、田中修平、木戸脇彩
特願2012-47585
Ras機能阻害剤のスクリーニング方法, (2011), 片岡徹、島扶美、田村厚夫、荒木望嗣
特願2011-23695
レアメタル結合能を有する人工ペプチドおよびその利用, (2012), 田村厚夫、飯田禎弘
   2011年
論文
Kousuke Matsumoto, Fumi Shima, Shin Muraoka, Mitsugu Araki, Lizhi Hu, Yuichi Ijiri, Rina Hirai, Jingling Liao, Takashi Yoshioka, Takashi Kumasaka, Masaki Yamamot, Atsuo Tamura, and Tohru Kataoka (2011) Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring a-helix on conformational dynamics of the GTP-bound Ras family small GTPases J. Biol. Chem., 286, 15403-15412.
Mitsugu Araki, Fumi Shima, Yoko Yoshikawa, Shin Muraoka, Yuichi Ijiri, Yuka Nagahara, Tomoya Shirono, Tohru Kataoka, and Atsuo Tamura (2011) Solution Structure of the State 1 Conformation of GTP-bound H-Ras Protein: Implication for the Role of the Conformational Dynamics in Its Signaling Functions J. Biol. Chem., 286, 39644-39653.
   2010年
論文
Naoki Yamamoto & Atsuo Tamura (2010) Designed low amphipathic peptides with α-helical propensity exhibiting antimicrobial activity via a lipid domain formation mechanism PEPTIDES, 31, 794-805.
Satoru Itoh, Atsuo Tamura & Yuko Okamoto (2010) Helix-Hairpin Transitions of a Designed Peptide Studied by a Generalized-Ensemble Simulation J. Chemical Theory and Computation, 6, 979-983.
Ohki Kambara, Atsuo Tamura, Takashi Uchino, Kohji Yamamoto, and Keisuke Tominaga (2010) Terahertz time-domain spectroscopy of poly-L-lysine Biopolymers, 93, 735-739.
Fumi Shima, Yuichi Ijiri, Shin Muraoka1, Jingling Liao, Min Ye, Mitsugu Araki, Kosuke Matsumoto, Naoki Yamamoto, Takeshi Sugimoto, Yoko Yoshikawa, Takashi, Kumasaka, Masaki Yamamoto, Atsuo Tamura and Tohru Kataoka (2010) Structural basis for conformational dynamics of GTP-bound Ras protein J. Biol. Chem., 285, 22696-22705.
国際特許
PCT/JP2010/061821
MUTANT RAS POLYPEPTIDE CRYSTAL, (2010), Tohru Kataoka,Fumi Shima, Atsuo Tamura, Takashi Kumasaka
国内特許
特許第4448947号 取得
ナノファイバー形成能を有するペプチド、及びペプチドナノファイバー (2010) 鬼塚健太郎、田中修平、田村厚夫、杉原宏和
特許第4448948号 取得
ペプチドで構成されるナノファイバーとその製法(2010) 田村厚夫
特許第4448949号 取得
導電性ペプチドナノファイバー及びその製造方法(2010) 鬼塚健太郎、田中修平、杉原宏和、田村厚夫
   2009年
論文
Daizo Hamada, Toshiki Tanaka, Gian Gaetano Tartaglia, Amol Pawar, Michele Vendruscolo, Mei Kawamura, Atsuo Tamura, Naoki Tanaka, & Christopher M. Dobson (2009) Competition between folding, native state dimerisation and amyloid aggregation in β-lactoglobulin J. Mol. Biol., 386, 878-890.
Mitsugu Araki, Atsuo Tamura (2009) Solubility-dependent structural formation of a 25-residue, natively unfolded protein, induced by addition of a seven-residue peptide fragment FEBS Journal, 276(8), 2336-2347.
国内特許
特願2009-165717
変異型Rasポリペプチドの結晶, (2009), 片岡 徹、島 扶美、田村 厚夫、熊坂 崇
   2008年
論文
Ohki kambara, Atsuo Tamura, Akira Naito and Keisuke Tominaga (2008) Structural changes of poly-L-lysine in solution and lyophilized form Phys. Chem. Chem. Phys., 10(33), 5042-5044.
Jingling Liao, Fumi Shima, Mitsugu Araki, Min Ye, Shin Muraoka, Takeshi Sugimoto, Mei Kawamura, Naoki Yamamoto, Atsuo Tamura and Tohru Kataoka (2008) Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics BBRC, 2(2), 327-332.
Tomohiro Imamura, Naoki Yamamoto, Atsuo Tamura, Shinji Murabayashi, Shigeki Hashimoto, Hiroaki Shimada and Seiichi Taguchi (2008) NMR based structure--activity relationship analysis of an antimicrobial peptide, thanatin, engineered by site-specific chemical modification: Activity improvement and spectrum alteration BBRC, 369(2), 609-615
国際特許
米国特許Patent No.7449445 取得
CONDUCTIVE PEPTIDE NANOFIBER AND METHOD OF MANUFACTURE THE SAME, (2008), Kentaro Onizuka, Shuhei Tanaka, Hirokazu Sugihara, Atsuo Tamura
   2007年
論文
Mitsugu Araki and Atsuo Tamura. (2007) Transformation of an α-helix peptide into a β-hairpin induced by addition of a fragment results in creation of a coexisting state. PROTEINS: Structure, Function, and Bioinformatics, 66, 860-868.
国内特許
特願2007-59243
高分子材料およびその製造方法, (2007), 田中修平、田村厚夫
特願2007-59244
高分子材料およびその製造方法, (2007), 田中修平、田村厚夫、武井俊朗
   2006年
論文
Nobuyuki Nakanishi, Fusako Takeuchi, Hidetsugu Okamoto, Atsuo Tamura, hiroshi Hori, & Motonari Tsubaki (2006) Characterization of heme-coordinating histidyl residues of cytochrome b5 based on the reactivity with diethylpyrocarbonate: A mechanism for the opening of axial imidazole rings. J. Biochem., 140, 561-571.
国内特許
特願2006-053253
金属イオン結合能およびナノチューブ形成能を有する環状ペプチドと、それを用いたペプチドで構成されるナノチューブ、並びにそれらの製造方法, (2006), 田村厚夫、田中修平、木戸脇彩
   2005年
論文
Kohji Yamamoto, Keisuke Tominaga, Hiroaki Sasakawa, Atsuo Tamura, Hidetoshi Murakami, Hideyuki Ohtake & Nobuhiko Sarukura. (2005) Terahertz Time-Domain Spectroscopy of Amino Acids and Polypeptides. Biophys. J., 89(3), L22-L24.
Min Ye, Fumi Shima, Shin Muraoka, Jingling Liao, Hidetsugu Okamoto, Masaki Yamamoto, Atsuo Tamura, Naoto Yagi, Tatzuo Ueki & Tohru Kataoka. (2005) Crystal structure of M-Ras reveals a GTP-bound “off” state conformation of Ras family small GTPases. J. Biol. Chem., 280, 31267-31275.
Hideyuki Mukai, Takayuki Isagawa, Emiko Goyama, Shuhei Tanaka, Neil F. Bence, Atsuo Tamura, Yoshitaka Ono & Ron R. Kopito. (2005) Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells. Proc. Natl. Acad. Sci. USA., 102, 10887-10892.
国際特許
米国特許出願No.11/252,719
CONDUCTIVE PEPTIDE NANOFIBER AND METHOD OF MANUFACTURE THE SAME, (2005), Kentaro Onizuka, Shuhei Tanaka, Hirokazu Sugihara, Atsuo Tamura
PCT/JP2005/22619
低温活性型サチライシン, (2005), 田村厚夫、川端正憲
   2004年
論文
Yongjin Zhu, Xiaoran Fu, Ting Wang, Atsuo Tamura, Shoji Takada, Jeffery G. Saven & Feng Gai. (2004) Guiding the search for a protein's maximum rate of folding. Chem. Phys., 307, 99-109.
Shuhei Tanaka, Shuichi Kojima & Atsuo Tamura. (2004) Mapping the position of the transition state in the folding of a small α/β protein, POIA1. Chem. Phys., 307, 233-242.
Kumiko Yonehara & Atsuo Tamura. (2004) Structural Characterization of Fibrillar Aggregates of Proteins by Mass Spectrometry. J. Mass Spectrom. Soc. Jpn., 52, 102-105.
Sayuri Morimoto & Atsuo Tamura. (2004) Key Elements for Protein Foldability Revealed by a Combinatorial Approach among Similarly Folded but Distantly Related Proteins. Biochemistry, 43, 6596-6605.
国内特許
特願2004-151698
ナノファイバー形成能を有するペプチド、及びペプチドナノファイバー, (2004), 鬼塚健太郎、田中修平、田村厚夫、杉原宏和
特願2004-308542
導電性ペプチドナノファイバー及びその製造方法, (2004), 発明者:鬼塚健太郎、田中修平、杉原宏和、田村厚夫
特願2004-359336
低温活性型サチライシン, (2004), 川端正憲、田村厚夫
   2003年
論文
Wenzhen Jin, Ohki Kambara, Hiroaki Sasakawa, Atsuo Tamura, & Shoji Takada. (2003) De Novo Design of Foldable Proteins with Smooth Folding Funnel: Automated Negative Design and Experimental Verification. Structure, 11, 581-590.
国内特許
特願2003-385670
ペプチドで構成されるナノファイバーとその製法, (2003), 田村厚夫
   2002年
論文
Masayuki Oda, Atsuo Tamura, Kenji Kanaori, Shuichi Kojima, Kin-ichiro Miura, Keiko Momma, Ben'ichiro Tonomura, & Kazuyuki Akasaka. (2002) Functional tolerance of Streptomyces subtilisin inhibitor toward conformational and stability changes caused by single-point mutations in the hydrophobic core. J. Biochem., 132, 991-995.
Tomoko Nakagawa, Hirotaka Shimizu, Karl Link, Akiko Koide, Shohei Koide, & Atsuo Tamura. (2002) Calorimetric dissection of thermal unfolding of OspA, a predominantly beta-sheet protein containing a single-layer beta-sheet. J. Mol. Biol., 323, 751-762.
Hiroaki Sasakawa, Sosuke Yoshinaga, Shuichi Kojima, & Atsuo Tamura. (2002) Structure of POIA1, a homologous protein to the propeptide of subtilisin. Implication for protein foldability and the function as an intramolecular chaperone. J. Mol. Biol., 317, 159-167.
Kohji Yamamoto, Keisuke Tominaga, Hiroaki Sasakawa, Atsuo Tamura, Hidetoshi Murakami, Hideyuki Ohtake & Nobuhiko Sarukura (2002) Far-infrared absorption measurements of polypeptides and cytochrome c by THz radiation. Bull. Chem. Soc. Jpn., 75, 1083-1092.
   2001年
論文
Xiaolin Huang, Tomoko Nakagawa, Atsuo Tamura, Karl Link, Akiko Koide, & Shohei Koide. (2001) Formation of the sigle-layer beta-sheet of Borrelia burgdorferi OspA in the absence of a capping globular domain. J. Mol. Biol., 308, 367-375.
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