研究業績（大﨑，大学院生，corresponding author*）

2023年

1) Morito S, Yasui H, Itoh T, Kamoshida S, Ohsaki H*.
Malignant mesothelioma cells with characteristic intracytoplasmic vacuolization and lipids.
Diagn Cytopathol.2023 Dec;51(12):E328-E331.

2) Suzuki K, Ogawa D, Kanda T, Fujimori T, Shibayama Y, Rahman A, Ye J, Ohsaki H, Akimitsu K, Izumori K, Tamiya T, Nishiyama A, Miyake K*.
Antiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma.
Sci Rep.2023 Nov 9;13(1):19515.

3) Irino S, Ose H, Takata N, Kamoshida S, Ohsaki H*.
Barriers to undergoing cervical cancer screening among health sciences university students in Japan: A cross-sectional study.
Nurs Health Sci. 2023 Sep;25(3):466-473.

4) Jahan N, Ohsaki H, Kaneko K, Rahman A, Nishiyama T, Koizumi M, Yamanaka S, Kitada K, Sugiura Y, Matsui K, Yokoo T, Hamano T, Kuro-O M, Itou T, Suzuki M, Ueda K, Nishiyama A*.
Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins.
Sci Rep. 2023 Mar 29;13(1):5161.

5) Sakumo K, Morihashi K, Nakamura A, Nukaya T, Sumitomo M, Nakamura M, Sofue T, Haba R, Itoh T, Kamoshida S, Ohsaki H*.
The usefulness of nuclear area in the diagnosis of high-grade urothelial carcinoma cells in voided urine cytology.
Cytopathology. 2023 Jul;34(4):295-301.

2022年

1) Maekawa K*, Kotera S, Ohsaki H.
Competency for Japanese novice medical laboratory scientists: a Delphi method.
BMC Med Educ. 2022 Dec 16;22(1):875.

2) Hattori M, Rahman A, Kidoguchi S, Jahan N, Fujisawa Y, Morisawa N, Ohsaki H, Kobara H, Masaki T, Hossain A, Steeve A, Nishiyama A*.
Association of Antihypertensive Effects of Esaxerenone with the Internal Sodium Balance in Dahl Salt-Sensitive Hypertensive Rats.
Int J Mol Sci. 2022 Aug 10;23(16):8915.

3) Izutsu M, Domoto T, Kamoshida S*, Ohsaki H, Matsuoka H, Umeki Y, Shiogama K, Hirayama M, Suda K, Uyama I.
Expression status of p53 and organic cation transporter 1 is correlated with poor response to preoperative chemotherapy in esophageal squamous cell carcinoma.
World J Surg Oncol. 2022 Apr 1;20(1):105.

4) Sakane J, Kitayama H, Inoue T, Nakamura A, Yamada M, Miyama Y, Kawamura H, Iwafuchi H, Kamoshida S, Ohsaki H*.
Urinary Podocyte Count as a Potential Routine Laboratory Test for Glomerular Disease: A Novel Method Using Liquid-Based Cytology and Immunoenzyme Staining.
Acta Cytol. 2022;66(5):434-440.

5) Morinishi T, Tokuhara Y, Kajihara K, Kawakami S, Tanaka S, Ohsaki H, Matsunaga T, Ibuki E, Hirakawa E*.
Peroxisome proliferator-activated receptor-α expression is associated with histological type in human gastric carcinoma.
Mol Clin Oncol. 2022 Feb;16(2):51.

6) Tanaka S, Tokuhara Y, Hosokawa S, Ohsaki H, Morinishi T, Yamamoto T, Teramoto N, Hirakawa E*.
Overexpression of the PPAR-γ protein in primary Ta/T1 non-muscle-invasive urothelial carcinoma.
Mol Clin Oncol. 2022 Feb;16(2):36.

7) Kidoguchi S, Kitada K, Nakajima K, Nakano D, Ohsaki H, Kittikulsuth W, Kobara H, Masaki T, Yokoo T, Takahashi K, Titze J, Nishiyama A*.
Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
Life Sci. 2022 Jan 15;289:120192.

2021年

1) Enomoto K, Matsunaga T, Sofue T, Nakamura A, Hirakawa E, Ibuki E, Haba R, Kamoshida S, Ohsaki H*.
p53 expression in repair/reactive renal tubular cells: A potential pitfall leading to a false-positive diagnosis of urine cytology.
Cancer Med. 2021 Dec;10(24):8846-8853.

2) Rodriguez R, Lee AY, Godoy-Lugo JA, Martinez B, Ohsaki H, Nakano D, Parkes DG, Nishiyama A, Vázquez-Medina JP, Ortiz RM*.
Chronic AT1 blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats.
Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E714-E727.

3) Ohsaki H*, Ueda K, Minakawa T, Oshiro M, Kamoshida S, Sugiura Y, Suzuki M, Nishiyama A.
Cytologic features of oral squamous cell carcinoma in an Indo- Pacific bottlenose dolphin (Tursiops aduncus): Papanicolaou stain and immunocytochemistry using liquid-based cytology.
Vet Clin Pathol. 2021 Sep;50(3):404-409.

4) Morito S, Nitanda T, Tsukamoto R, Kamoshida S, Yasui H, Itoh T, Ohsaki H*.
Rapid Cell Transfer by Means of Nylon Mesh to Improve Cellular Diagnosis: The Role of Immunocytochemistry.
Acta Cytol. 2021;65(5):424-429.

5) Okuda C, Kyotake A, Nakamura A, Itoh T, Kamoshida S, Ohsaki H*.
Quantitative cytomorphological comparison of SurePath and ThinPrep liquid-based cytology using high-grade urothelial carcinoma cells.
Cytopathology. 2021 Sep;32(5):654-659.

6) Rahman A, Sawano T, Sen A, Hossain A, Jahan N, Kobara H, Masaki T, Kosaka S, Kitada K, Nakano D, Imamura T, Ohsaki H, Nishiyama A*.
Cardioprotective Effects of a Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, in Dahl Salt- Sensitive Hypertensive Rats.
Int J Mol Sci. 2021 Feb 19;22(4):2069.

2020年以前

1) Shibayama Y, Takahashi K, Yamaguchi H, Yasuda J, Yamazaki D, Rahman A, Fujimori T, Fujisawa Y, Takai S, Furukawa T, Nakagawa T, Ohsaki H, Kobara H, Wong JH, Masaki T, Yuzawa Y, Kiyomoto H, Yachida S, Fujimoto A, Nishiyama A*.
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H.
Commun Biol. 2020 Nov 27;3(1):724.

2) Li L, Nakano D, Zhang A, Kittikulsuth W, Morisawa N, Ohsaki H, Suzuki N, Yamamoto M, Nishiyama A*.
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice.
J Pharmacol Sci. 2020 Dec;144(4):229-236.

3) Hosokawa S, Shukuya K, Sogabe K, Ejima Y, Morinishi T, Hirakawa E, Ohsaki H, Shimosawa T, Tokuhara Y*.
Novel absorbance peak of gentisic acid following the oxidation reaction.
PLoS One. 2020 Apr 29;15(4):e0232263.

4) Siddique SM, Kubouchi K, Shinmichi Y, Sawada N, Sugiura R, Itoh Y, Uehara S, Nishimura K, Okamura S, Ohsaki H, Kamoshida S, Yamashita Y, Tamura S, Sonoki T, Matsuoka H, Itoh T, Mukai H*.
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.
Sci Rep. 2019 Sep 27;9(1):13977.

5) Morinishi T, Tokuhara Y, Ohsaki H, Ibuki E, Kadota K, Hirakawa E*.
Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma.
PPAR Res. 2019 Jul 3;2019:7486727.

6) Sakanashi F, Shintani M, Tsuneyoshi M, Ohsaki H, Kamoshida S*.
Apoptosis, necroptosis and autophagy in colorectal cancer: Associations with tumor aggressiveness and p53 status.
Pathol Res Pract. 2019 Jul;215(7):152425.

7) Wang J, Shibayama Y, Zhang A, Ohsaki H, Asano E, Suzuki Y, Kushida Y, Kobara H, Masaki T, Wang Z, Nishiyama A*.
(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations.
Br J Cancer. 2019 Jan;120(2):229-237.

8) Tsukamoto R,　Ohsaki H*, Hosokawa S, Tokuhara Y, Kamoshida S, Sakuma T, Itoh T, Ohbayashi C.
Qualitative and quantitative cytomorphological features of primary anaplastic lymphoma kinase-positive lung cancer.
Cytopathology. 2019 May;30(3):295-300.

9) Okamura S, Osaki T, Nishimura K, Ohsaki H, Shintani M, Matsuoka H, Maeda K, Shiogama K, Itoh T, Kamoshida S*.
Thymidine kinase-1/CD31 double immunostaining for identifying activated tumor vessels.
Biotech Histochem. 2019 Jan;94(1):60-64.

10) Tokuhara Y*, Shukuya K, Tanaka M, Sogabe K, Ejima Y, Hosokawa S, Ohsaki H, Morinishi T, Hirakawa E, Yatomi Y, Shimosawa T.
Absorbance measurements of oxidation of homogentisic acid accelerated by the addition of alkaline solution with sodium hypochlorite pentahydrate.
Sci Rep. 2018 Jul 27;8(1):11364.

11) Ohsaki H*, Matsunaga T, Fujita T, Tokuhara Y, Kamoshida S, Sofue T.
Quantifying Podocytes and Parietal Epithelial Cells in Human Urine Using Liquid- based Cytology and WT1 Immunoenzyme Staining.
Bio Protoc. 2018 May 5;8(9):e2827.

12) Tokuhara Y, Morinishi T, Matsunaga T, Sakai M, Sakai T, Ohsaki H, Kadota K, Kushida Y, Haba R, Hirakawa E*.
Nuclear expression of claudin-3 in human colorectal adenocarcinoma cell lines and tissues.
Oncol Lett. 2018 Jan;15(1):99-108.

13) Sofue T*, Kushida Y, Ozaki T, Moritoki M, Nishijima Y, Ohsaki H, Ueda N, Kakehi Y, Nishiyama A, Minamino T.
Tubular Cell Senescence in the Donated Kidney Predicts Allograft Function, but Not Donor Remnant Kidney Function, in Living Donor Kidney Transplantation.
Am J Nephrol. 2018;47(1):8-17.

14) Fujita T, Sofue T, Moritoki M, Nishijima Y, Tokuhara Y, Wakisaka H, Kushida Y, Haba R, Ohsaki H*.
Urinary WT1-positive cells as a non-invasive biomarker of crescent formation.
Cytopathology. 2017 Dec;28(6):524-530.

15) Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, Matsuo K, Nakayama T, Satoh R, Sugiura R, Abe M, Sakimura K, Wakana S, Ohsaki H, Kamoshida S, Mukai H*.
Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.
Sci Rep. 2017 Aug 9;7(1):7663.

16) Tokuhara Y, Morinishi T, Matsunaga T, Ohsaki H, Kushida Y, Haba R, Hirakawa E*.
Claudin-1, but not claudin-4, exhibits differential expression patterns between well- to moderately-differentiated and poorly-differentiated gastric adenocarcinoma.
Oncol Lett. 2015 Jul;10(1):93-98.

17) Yamanushi TT, Boyett MR, Yamamoto Y, Ohsaki H, Hirakawa E, Dobrzynski H*.
Comparison of formaldehyde and methanol fixatives used in the detection of ion channel proteins in isolated rat ventricular myocytes by immunofluorescence labelling and confocal microscopy.
Folia Morphol (Warsz). 2015;74(2):258-61.

18) Ohsaki H*, Sofue T, Kawakami K, Nishijima Y, Hara T, Matsunaga T, Kushida Y, Haba R, Shigematsu Y, Irino S.
WT1 immunoenzyme staining using SurePath processed urine cytology helps to detect kidney disease.
Cytopathology. 2016 Feb;27(1):43-9.

19) Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, Nishiyama A*.
Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy.
J Diabetes Complications. 2014 Sep- Oct;28(5):604-11.

20) Ohsaki H*, Shigematsu Y, Irino S, Hirakawa E.
Comparison of two liquid preservatives for SurePath™ slides prepared from voided urine.
Diagn Cytopathol. 2014 May;42(5):423-7.

21) Nishioka S, Nakano D, Kitada K, Sofue T, Ohsaki H, Moriwaki K, Hara T, Ohmori K, Kohno M, Nishiyama A*.
The cyclin-dependent kinase inhibitor p21 is essential for the beneficial effects of renal ischemic preconditioning on renal ischemia/reperfusion injury in mice.
Kidney Int. 2014 Apr;85(4):871-9.

22) Norimatsu Y, Ohsaki H, Masuno H, Kagawa A, Teramoto N, Kobayashi TK*.
Efficacy of CytoLyt® hemolytic action on ThinPrep® LBC using cultured osteosarcoma cell line LM8.
Acta Cytol. 2014;58(1):76-82.

23) Kawanishi N, Norimatsu Y, Ohsaki H, Yuminamochi T, Katoh R, Okusaki K, Sato Y, Kobayashi TK*.
Diagnosis of pseudopapillary variant of medullary thyroid carcinoma by fine-needle aspiration cytology.
Diagn Cytopathol. 2014 Sep;42(9):823-6.

24) Norimatsu Y, Sakamoto S, Ohsaki H, Ozaki S, Yokoyama T, Shimizu K, Yanoh K, Akiyama M, Bamba M, Kobayashi TK*.
Cytologic features of the endometrial adenocarcinoma: comparison of ThinPrep and BD SurePath preparations.
Diagn Cytopathol. 2013 Aug;41(8):673-81.

25) Norimatsu Y, Shigematsu Y, Sakamoto S, Ohsaki H, Yanoh K, Kawanishi N, Kobayashi TK*.
Nuclear characteristics of the endometrial cytology: liquid-based versus conventional preparation.
Diagn Cytopathol. 2013 Feb;41(2):120-5.

26) Norimatsu Y, Kawai M, Kamimori A, Yuminamochi T, Ohsaki H, Yanoh K, Kawanishi N, Kobayashi TK*.
Endometrial glandular and stromal breakdown, Part 4: Cytomorphology of "condensed cluster of stromal cells including a light green body".
Diagn Cytopathol. 2012 Mar;40(3):204-9.

27) Ohsaki H*, Hirouchi T, Hayashi N, Okanoue E, Ohara M, Kuroda N, Hirakawa E.
Diagnostic value of urine erythrocyte morphology in the detection of glomerular disease in SurePath™ liquid-based cytology compared with fresh urine sediment examination.
Cytopathology. 2013 Feb;24(1):52-7.

28) Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley- Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A*.
Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.
Am J Hypertens. 2012 May;25(5):604-11.

29) Ohsaki H*, Nakamura M, Arie K, Hirakawa E, Haba R.
Endometriosis of sigmoid colon mimicking malignant tumor diagnosed by intraoperative imprint cytology.
Diagn Cytopathol. 2012 Feb;40(2):159-62.

30) Norimatsu Y, Shigematsu Y, Sakamoto S, Ohsaki H, Yanoh K, Kawanishi N, Kobayashi TK*.
Nuclear features in endometrial cytology: comparison of endometrial glandular and stromal breakdown and endometrioid adenocarcinoma grade 1.
Diagn Cytopathol. 2012 Dec;40(12):1077-82.

31) Norimatsu Y, Ohsaki H, Yanoh K, Kawanishi N, Kobayashi TK*.
Expression of immunoreactivity of nuclear findings by p53 and cyclin a in endometrial cytology: Comparison with endometrial glandular and stromal breakdown and endometrioid adenocarcinoma grade 1.
Diagn Cytopathol. 2013 Apr;41(4):303-7.

32) Fan YY, Kohno M, Hitomi H, Kitada K, Fujisawa Y, Yatabe J, Yatabe M, Felder RA, Ohsaki H, Rafiq K, Sherajee SJ, Noma T, Nishiyama A, Nakano D*.
Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney.
Endocrinology. 2011 Feb;152(2):680-8.

33) Ohsaki H*, Hirakawa E, Nakamura M, Norimatsu Y, Kiyomoto H, Haba R.
Expression of vimentin and high-molecular-weight cytokeratin (clone 34ßE12) in differentiating reactive renal tubular cells from low-grade urothelial carcinoma cells in voided urine.
Cytopathology. 2011 Aug;22(4):247-52.

34) Fan YY, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A*.
Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte.
J Hypertens. 2010 May;28(5):1034-43.

35) Ohsaki H*, Hirakawa E, Kushida Y, Yokoshita S, Nakamura M, Kiyomoto H, Haba R.
Can cytological features differentiate reactive renal tubular cells from low- grade urothelial carcinoma cells?
Cytopathology. 2010 Oct;21(5):326-33.

36) Ohsaki H*, Hirakawa E, Kagawa K, Nakamura M, Kiyomoto H, Haba R.
Value of computer-assisted quantitative nuclear morphometry for differentiation of reactive renal tubular cells from low-grade urothelial carcinoma.
Cytopathology. 2010 Oct;21(5):334-8.

37) Norimatsu Y, Kawanishi N, Shigematsu Y, Kawabe T, Ohsaki H, Kobayashi TK*.
Use of liquid-based preparations in urine cytology: An evaluation of Liqui-PREP and BD SurePath.
Diagn Cytopathol. 2010 Sep;38(9):702-4.

38) Ohsaki H*, Haba R, Matsunaga T, Nakamura M, Kiyomoto H, Hirakawa E.
'Cannibalism' (cell phagocytosis) does not differentiate reactive renal tubular cells from urothelial carcinoma cells.
Cytopathology. 2009 Aug;20(4):224-30.

39) Ohsaki H*, Hirakawa E, Kushida Y, Kadota K, Ishikawa M, Haba R.
Cytological features of carcinoma of the collecting ducts of Bellini in voided urine cytology.
Diagn Cytopathol. 2009 Sep;37(9):676-9.

40) Hata K*, Watanabe Y, Nakai H, Minami T, Ohsaki H, Hirakawa E, Hoshiai H.
Association of metastin/a G-protein-coupled receptor signaling and Down syndrome critical region 1 in epithelial ovarian cancer.
Anticancer Res. 2009 Feb;29(2):617-23. PMID: 19331211.

41) Ohsaki H*, Haba R, Matsunaga T, Nakamura M, Kiyomoto H, Hirakawa E.
Cytomorphologic and immunocytochemical characteristics of reactive renal tubular cells in renal glomerular disease.
Acta Cytol. 2008 May-Jun;52(3):297-303.

42) Ohsaki H*, Nakamura M, Kagawa A, Yamanushi TT, Kushida Y, Haba R, Hirakawa E.
Fine needle aspiration cytology of an enlarged inguinal lymph node.
Cytopathology. 2008 Dec;19(6):389-93.

43) Tonai T*, Shiba K, Taketani Y, Ohmoto Y, Murata K, Muraguchi M, Ohsaki H, Takeda E, Nishisho T.
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
J Neurochem. 2001 Sep;78(5):1064-72.